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Abstract #3883

Synthesized versus acquired high b-value (1200 s/mm2) diffusion-weighted magnetic resonance imaging for detection of peripheral zone lesions in the prostate using PI-RADS version 2

Stephanie T. Chang1, Andreas M. Loening1, and Shreyas S. Vasanawala1

1Radiology, Stanford University, Palo Alto, CA, United States

Greater diffusion weighting is generally thought to increase performance of MRI for prostate cancer detection. We compared acquired high b-value (1200 s/mm2) diffusion-weighted MRI against b-1200 images synthesized from b ≤ 800 acquisitions for detection of peripheral zone lesions in the prostate for 50 consecutive patients undergoing prostate MRI and biopsy using two blinded independent readers. Although subjective image quality was rated slightly but significantly worse for synthesized DWI compared to acquired DWI images, no significant difference in detection of peripheral zone lesions, PI-RADS version 2 lesion categorization, or confidence scores of interpretation were observed.

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