Abstract #3885

Assessment of metabolism in the placenta by hyperpolarized MRI

Emmeli F. R. Mikkelsen¹, Per Mose Nielsen², Haiyun Qi¹, Thomas S. Nørlinger¹, Hans Stødkilde-Jørgensen¹, Niels Uldbjerg³, Michael Pedersen¹, Puk Sandager³, and Christoffer Laustsen¹

¹MRI Research Centre, Aarhus University Hospital, Aarhus N, Denmark, ²Department of Clinical Medicine, Aarhus University Hospital, Aarhus N, Denmark, ³Department of Obstetrics and Gynaecology, Aarhus University Hospital, Aarhus N, Denmark

Glucose is the main energy source for the placenta and the fetus and is essential for normal growth and development of the fetus. It has previously been shown that the placenta itself consumes about half of the glucose supplied, metabolizing a great amount to lactate. Hyperpolarized Magnetic Resonance Imaging (MRI) is a novel non-harmful method for monitoring metabolic processes in tissues in real time. We evaluate the metabolism of [1-¹³C]-pyruvate in the placenta and fetus in a novel pregnancy rodent model by the use of hyperpolarized MRI.

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