Abstract #3893

In Vitro and in Vivo MR measurement of fetal blood oxygen saturation

Fabian Kording¹, Hendrik Kooijman², Jin Yamamura¹, Manuela Tavares³, Mathias Kladeck¹, Kurt Hecher³, Gerhard Adam¹, and Bjoern Schoennagel¹

¹Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ²Philips Medical Systems, Hamburg, Germany, ³Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Intrauterine growth restriction is associated with a decreased oxygen availability. In clinical practice, indicators such as Doppler changes of the ductus venosus and umbilical artery are measured and a direct measurement using MR oximetry would be desirable. The relationship between T2 relaxation time and oxygen saturation (sO2) is determined in in-vitro fetal blood samples and the feasibility of a noninvasively determination of fetal sO2 is evaluated. The calculated fetal sO2 highly correlated with measured sO2 values and determined parameters were successfully evaluated in-vivo in the left fetal ventricle.

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