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Abstract #3893

In Vitro and in Vivo MR measurement of fetal blood oxygen saturation

Fabian Kording1, Hendrik Kooijman2, Jin Yamamura1, Manuela Tavares3, Mathias Kladeck1, Kurt Hecher3, Gerhard Adam1, and Bjoern Schoennagel1

1Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 2Philips Medical Systems, Hamburg, Germany, 3Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Intrauterine growth restriction is associated with a decreased oxygen availability. In clinical practice, indicators such as Doppler changes of the ductus venosus and umbilical artery are measured and a direct measurement using MR oximetry would be desirable. The relationship between T2 relaxation time and oxygen saturation (sO2) is determined in in-vitro fetal blood samples and the feasibility of a noninvasively determination of fetal sO2 is evaluated. The calculated fetal sO2 highly correlated with measured sO2 values and determined parameters were successfully evaluated in-vivo in the left fetal ventricle.

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