Abstract #3896

First Trimester Alcohol Exposure Alters Placental Perfusion and Fetal Oxygen Transport in a Pregnant Non-Human Primate Model

Jamie O. Lo¹, Matthias C. Schabel¹, Victoria H.J. Roberts², Xiaojie Wang², Kathleen A. Grant², Antonio E. Frias^1,2, and Christopher D. Kroenke^1,2

¹Oregon Health & Science University, Portland, OR, United States, ²Oregon National Primate Research Center, Beaverton, OR, United States

Alcohol consumption in pregnancy adversely affects fetal growth and development, likely secondary to altered placental perfusion resulting in decreased fetal oxygen availability. We developed a novel MRI technique that allows in-vivo assessment and correlation of placental perfusion and oxygenation. Our study demonstrated reduced placental perfusion and oxygenation with first trimester ethanol exposure in a pregnant nonhuman primate model using a novel MRI method and Doppler ultrasound. Impaired fetal growth was also observed. These findings suggest that discontinuation of alcohol consumption after the first trimester is associated with decreased placental perfusion and oxygenation subsequently affecting fetal growth and development.

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