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Abstract #3916

Longitudinal Evaluation of Brown Adipose Tissues in Rats By  Multi-Modal Imaging

Sanjay Kumar Verma1, Bhanu Prakash KN1, Jadegoud Yaligar1, Julian Goggi1, Venkatesh Gopalan1, Swee Shean Lee1, Tian Xianfeng1, Shigeki Sugii2, Melvin Khee Shing Leow3,4, Kishore Bhakoo1, and S. Sendhil Velan1

1Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, 2Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Singapore, 3Singapore Institute for Clinical Sciences, Singapore, 4Department of Endocrinology, Tan Tock Seng Hospital, Singapore

There are two types of fat tissues, white adipose tissue (WAT) and brown adipose tissue (BAT), which essentially perform opposite functions in whole body energy metabolism. Cold exposure activates adrenergic receptor in the brown adipose tissues, and improve the separation of WAT and BAT. In this study we have evaluated the longitudinal changes of fat fraction (FF), and relaxation times (T2 and T2*) of interscapular brown adipose tissue (BAT) of rats under thermoneutral and short term cold exposure, and validated with histology and UCP1. PET-CT was performed to visualize the activated BAT.

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