Abstract #3916

Longitudinal Evaluation of Brown Adipose Tissues in Rats By Multi-Modal Imaging

Sanjay Kumar Verma¹, Bhanu Prakash KN¹, Jadegoud Yaligar¹, Julian Goggi¹, Venkatesh Gopalan¹, Swee Shean Lee¹, Tian Xianfeng¹, Shigeki Sugii², Melvin Khee Shing Leow^3,4, Kishore Bhakoo¹, and S. Sendhil Velan¹

¹Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, ²Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Singapore, ³Singapore Institute for Clinical Sciences, Singapore, ⁴Department of Endocrinology, Tan Tock Seng Hospital, Singapore

There are two types of fat tissues, white adipose tissue (WAT) and brown adipose tissue (BAT), which essentially perform opposite functions in whole body energy metabolism. Cold exposure activates adrenergic receptor in the brown adipose tissues, and improve the separation of WAT and BAT. In this study we have evaluated the longitudinal changes of fat fraction (FF), and relaxation times (T₂ and T₂*) of interscapular brown adipose tissue (BAT) of rats under thermoneutral and short term cold exposure, and validated with histology and UCP1. PET-CT was performed to visualize the activated BAT.

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