Abstract #3954

Compressed Sensing 3D Echo Planar Spectroscopic Imaging of HIV Adults

Rajakumar Nagarajan¹, Zohaib Iqbal¹, Manoj K Sarma¹, Mario Guerrero ², Vanessa Correa ², Eric S Daar², and M.Albert Thomas¹

¹Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ²Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA, United States

HIV affects more than 1 million individuals In the US and over 40 million people worldwide. CNS is commonly involved in the early stage HIV infection. Conventional 3D MRSI is time-consuming because it involves a large number of phase encodings. EPSI approaches have been used to reduce the long acquisition time required for multiple spatial encoding steps. In our study, non-uniformly undersampled (NUS) semi LASER based 3D EPSI was used to quantitate changes in brain metabolites, NAA, Cr, Cho and myo-inositol in a group of HIV adults in comparison to age matched control sample using compressed sensing reconstruction by minimizing total variation.

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