Rajakumar Nagarajan1, Zohaib Iqbal1, Manoj K Sarma1, Mario Guerrero 2, Vanessa Correa 2, Eric S Daar2, and M.Albert Thomas1
1Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, 2Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA, United States
HIV
affects more than 1 million individuals In the US and over 40 million people
worldwide. CNS is commonly involved in the early stage HIV infection. Conventional
3D MRSI is time-consuming because it involves a large number of phase
encodings. EPSI approaches have been used to reduce the long acquisition time
required for multiple spatial encoding steps. In our study, non-uniformly undersampled (NUS) semi LASER based 3D
EPSI was used to quantitate changes in brain metabolites, NAA, Cr, Cho and
myo-inositol in a group of HIV adults in comparison to age matched control
sample using compressed sensing reconstruction by minimizing total variation.
