Abstract #3968

Energy metabolism in the rat cortex under thiopental anaesthesia measured in vivo by 13C MRS at 14.1T

Sarah Sonnay¹, Nathalie Just², Rolf Gruetter³, and João M.N. Duarte⁴

¹Laboratory of Functional and Metabolic Imaging (LIFMET), Ecole Polythechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ²Universitätsklinikum Münster, Münster, Germany, ³Center for Biomedical Imaging (CIBM) and Laboratory of Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁴Laboratory of Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

Cerebral function relies on cooperative interaction between neuronal and glial cells. Anaesthetics modulate basal neuronal activity, and therefore the so-called neurometabolic coupling, by targeting different receptors, such as γ-aminobutyric acid type A (GABA_A) receptors, in the case of thiopental or α-chloralose anaesthesia. We investigated cortical metabolism in vivo using ¹³C magnetic resonance spectroscopy (MRS) during infusion of [1,6-¹³C]glucose under thiopental anesthesia. Data indicate glycolysis inhibition, decreased mitochondrial oxidative metabolism and possible oxidation of three-carbon molecules, namely lactate, which plasma concentration increased two-fold (compared to α-chloralose anaesthesia).

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