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Abstract #3978

Standardisation and quantification of 23Na-MRI: repeatability and reproducibility of sodium imaging across two independent sites

Damien J. McHugh1,2, Frank Riemer2,3, Hamied A. Haroon1, Geoff J.M. Parker1,2,4, and Ferdia A. Gallagher2,3

1Centre for Imaging Sciences, The University of Manchester, Manchester, United Kingdom, 2CRUK & EPSRC Cancer Imaging Centre in Cambridge & Manchester, United Kingdom, 3Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 4Bioxydyn Ltd., Manchester, United Kingdom

This work investigates the repeatability and reproducibility of total sodium concentration (TSC) estimates in the human brain. Healthy volunteers were scanned twice at two different sites using comparable 3D Cones acquisitions, and region of interest TSC values were compared. Consistent TSC estimates were observed across repeated scans at different sites, and, for robust multi-site comparisons, a need was identified for standardisation of non-Cartesian data reconstruction. These preliminary results provide an initial step in the technical validation of sodium MRI-derived cancer biomarkers.

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