Abstract #4003

Hepatic lipid metabolite changes in high-fat diet induced liver steatosis model by in vivo 1H-MRS at 9.4T

Joo-Yeon Kim¹, Yeong-Jae Jeon^1,2, Sang-Woo Kim^1,2, and Hyeon-Man Baek^1,2

¹Bioimaging Reseach Team, Korea Basic Science Institute, Ochang, Korea, Republic of, ²Bio-Analytical Science, University of Science and Technology, Ochang, Korea, Republic of

The aim of this study was to characterize hepatic lipid metabolites changes in high-fat diet induced liver steatosis model using in vivo 1H-MRS. MR imaging an single-voxel 1H-MRS was performed using a PRESS sequence at 9.4T. Significant increase in lipid signals at 0.9, 1.3, 2.1, 2.3, 2.8, 4.1, 4.3, and 5.3 ppm was found in mice with high-fat diet (p<0.001). TL, TUB, UI, and Cho were increased with high-fat diet.Therefore, 1H-MRS is useful in detecting and characterizing various hepatic lipid alterations at early phase in mouse liver steatosis prior to development of fibrosis.

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