Meining Chen1, Gaiying Li1, Zhuwei Zhang1, Luguang Chen1, Mengchao Pei1, Xu Yan2, and Jianqi Li1
1Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, East China Normal University, Shanghai, China, People's Republic of, 2MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China, People's Republic of
Owing
to relatively low concentration of GABA in the brain, a large voxel size is normally
applied in MRS to achieve a high signal-to-noise ratio, but with combined
signal from white matter, gray matter and cerebrospinal fluid. The tissue contribution in GABA measurement
remains to be resolved. GABA levels from three closely adjacent voxels with
varied tissue composition in the anterior cingulate cortex were acquired by
using MEGA-PRESS. GABA level was found to be significantly higher in gray
matter than in white matter.
