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Abstract #4005

The anterior cingulate cortex GABA levels with varied tissue composition measured by in vivo single voxel MRS

Meining Chen1, Gaiying Li1, Zhuwei Zhang1, Luguang Chen1, Mengchao Pei1, Xu Yan2, and Jianqi Li1

1Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, East China Normal University, Shanghai, China, People's Republic of, 2MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China, People's Republic of

Owing to relatively low concentration of GABA in the brain, a large voxel size is normally applied in MRS to achieve a high signal-to-noise ratio, but with combined signal from white matter, gray matter and cerebrospinal fluid. The tissue contribution in GABA measurement remains to be resolved. GABA levels from three closely adjacent voxels with varied tissue composition in the anterior cingulate cortex were acquired by using MEGA-PRESS. GABA level was found to be significantly higher in gray matter than in white matter.

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