Abstract #4005

The anterior cingulate cortex GABA levels with varied tissue composition measured by in vivo single voxel MRS

Meining Chen¹, Gaiying Li¹, Zhuwei Zhang¹, Luguang Chen¹, Mengchao Pei¹, Xu Yan², and Jianqi Li¹

¹Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, East China Normal University, Shanghai, China, People's Republic of, ²MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China, People's Republic of

Owing to relatively low concentration of GABA in the brain, a large voxel size is normally applied in MRS to achieve a high signal-to-noise ratio, but with combined signal from white matter, gray matter and cerebrospinal fluid. The tissue contribution in GABA measurement remains to be resolved. GABA levels from three closely adjacent voxels with varied tissue composition in the anterior cingulate cortex were acquired by using MEGA-PRESS. GABA level was found to be significantly higher in gray matter than in white matter.

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