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Abstract #4007

Metabolite diffusion up to very high b in the mouse brain in vivo: revisiting the correlation between relaxation and diffusion properties

Clemence Ligneul1,2, Marco Palombo1,2, and Julien Valette1,2

1CEA/DSV/I2BM/MIRCen, Fontenay aux Roses, France, 2CNRS Université Paris-Saclay UMR 9199, Fontenay aux Roses, France

Diffusion-weighted magnetic resonance spectroscopy is performed in a large voxel in the mouse brain at two diffusion times, up to very high b-values. We combine different echo times and mixing times to investigate the potential interplay between relaxation properties and diffusion attenuation. Under current experimental conditions, we don’t observe any significant dependence of metabolite diffusion properties on TE/TM, except for water (and possibly NAA at very high b-values), which supports the interpretation and modeling of metabolite diffusion based primarily on geometry, irrespective of relaxation properties.

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