Abstract #4032

Multi-Parametric Imaging Assessment of Alzheimer’s Disease Pathology

Eva-Maria Ratai^1,2, Kimberly A. Stephens^1,2, Alison E. Goldblatt^1,2, Jean-Philippe Coutu^1,2, Ciprian Catana^1,2, Diana Rosas^2,3, and David Salat^1,2

¹Radiology, Massachusetts General Hospital, Boston, MA, United States, ²A. A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ³Neurology, Massachusetts General Hospital, Boston, MA, United States

The purpose of this study was to find associations between metabolites measures by MRS and glucose metabolism using FDG PET and cerebral blood flow (CBF) measured by ASL MRI in the assessment of Alzheimer’s Disease. Our study shows an association between increased myo-inositol, a marker of glial inflammation, and hypo-metabolism measured by FDG as well hypo-perfusion measured by ASL. Liner regression analysis revealed that creatine, a marker of altered energy metabolism positively correlated with increased glucose uptake by FDG PET. Increased levels of glutamate+glutamine (contributing to excitotoxicity) were related to decreased metabolic activity by PET and decreased CBF.

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