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Abstract #4054

Assessment of ferritin in the multiple sclerosis brain using temperature induced R2* changes

Christoph Birkl1, Daniele Carassiti2, Christian Langkammer1, Christian Enzinger1, Franz Fazekas1, Klaus Schmierer2,3, and Stefan Ropele1

1Department of Neurology, Medical University of Graz, Graz, Austria, 2Blizard Institute (Neuroscience), Queen Mary University of London, London, United Kingdom, 3Barts Health NHS Trust, Emergency Care and Acute Medicine Clinical Academic Group (Neuroscience), London, United Kingdom

Evidence for a possible role of iron in the pathogenesis and progression of multiple sclerosis (MS) has raised interest in iron mapping techniques. However, current approaches are not reliable in white matter because of the diamagnetic properties of myelin. We recently proposed a new method for iron mapping which is based on the temperature dependency of the paramagnetic susceptibility. Here, the temperature coefficient of R2* (TcR2*) as a measure of iron content was assessed in three post-mortem MS brain samples. Validation of TcR2* mapping was done with immunohistochemistry using cell counting on ferritin light-chain stains.

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