Abstract #4054

Assessment of ferritin in the multiple sclerosis brain using temperature induced R2* changes

Christoph Birkl¹, Daniele Carassiti², Christian Langkammer¹, Christian Enzinger¹, Franz Fazekas¹, Klaus Schmierer^2,3, and Stefan Ropele¹

¹Department of Neurology, Medical University of Graz, Graz, Austria, ²Blizard Institute (Neuroscience), Queen Mary University of London, London, United Kingdom, ³Barts Health NHS Trust, Emergency Care and Acute Medicine Clinical Academic Group (Neuroscience), London, United Kingdom

Evidence for a possible role of iron in the pathogenesis and progression of multiple sclerosis (MS) has raised interest in iron mapping techniques. However, current approaches are not reliable in white matter because of the diamagnetic properties of myelin. We recently proposed a new method for iron mapping which is based on the temperature dependency of the paramagnetic susceptibility. Here, the temperature coefficient of R₂* (TcR₂*) as a measure of iron content was assessed in three post-mortem MS brain samples. Validation of TcR₂* mapping was done with immunohistochemistry using cell counting on ferritin light-chain stains.

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