Abstract #4059

Ultra-high Resolution MRSI of Multiple Sclerosis at 7T

Bernhard Strasser¹, Gilbert Hangel¹, Michal Považan¹, Stephan Gruber¹, Marek Chmelík¹, Assunta Dal-Bianco², Fritz Leutmezer², Siegfried Trattnig^1,3, and Wolfgang Bogner¹

¹MRCE, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Department of Neurology, Medical University of Vienna, Vienna, Austria, ³Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

In this study fourteen MS patients were measured with an FID-based MRSI sequence at 7T with resolutions of 64x64 and 100x100. Metabolic maps of total NAA, total Choline, total Creatine, and myo-Inositol were compared to FLAIR images. All patients had lesions with decreased tNAA, and eight had increased myo-Inositol levels. However, not all lesions showed decreased tNAA values. Two patients showed decreased tNAA levels with no visible lesion on the FLAIR image. In average, a decrease of 26% in tNAA and an increase of 42% in myo-Inositol were observed in comparison to normal appearing white matter.

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