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Abstract #4059

Ultra-high Resolution MRSI of Multiple Sclerosis at 7T

Bernhard Strasser1, Gilbert Hangel1, Michal Považan1, Stephan Gruber1, Marek Chmelík1, Assunta Dal-Bianco2, Fritz Leutmezer2, Siegfried Trattnig1,3, and Wolfgang Bogner1

1MRCE, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Department of Neurology, Medical University of Vienna, Vienna, Austria, 3Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

In this study fourteen MS patients were measured with an FID-based MRSI sequence at 7T with resolutions of 64x64 and 100x100. Metabolic maps of total NAA, total Choline, total Creatine, and myo-Inositol were compared to FLAIR images. All patients had lesions with decreased tNAA, and eight had increased myo-Inositol levels. However, not all lesions showed decreased tNAA values. Two patients showed decreased tNAA levels with no visible lesion on the FLAIR image. In average, a decrease of 26% in tNAA and an increase of 42% in myo-Inositol were observed in comparison to normal appearing white matter.

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