Abstract #4083

MEMRI Detection of Neuronal Activity Following Acute and Chronic Nicotine Exposure in Rats

Aditya N Bade¹, Jingdong Dong², Howard E Gendelman¹, Michael D Boska^1,3, and Yutong Liu^1,3

¹Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Omaha, NE, United States, ²Second Affiliated Hospital, Dalian Medical University, Dalian, China, People's Republic of, ³Department of Radiology, University of Nebraska Medical Center, Omaha, Omaha, NE, United States

Rats with acute and chronic nicotine exposure were studied using manganese-enhanced MRI (MEMRI). Neuronal activity was found on nucleus accumbens and hippocampus in rats with acute nicotine exposure, and on nucleus accumbens and hippocampus, prefrontal and insular cortex. The neuronal activity was confirmed by immunohistology. The above-mentioned brain regions are believed to play roles in drug addiction. We demonstrate that MEMRI can be used to assess neuroadaptations from nicotine addiction.

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