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Abstract #4090

Diffusion-weighted MR Imaging and Spectroscopy reveal brain tissue alterations induced by ionizing radiation in the mouse brain

Elodie A. Pérès1,2, Fawzi Boumezbeur1, Olivier Etienne2, Antoine Grigis1, François D. Boussin2, and Denis Le Bihan1

1UNIRS, NeuroSpin, I2BM, Life Sciences Division, Commissariat à l’Energie Atomique, Gif-sur-Yvette, France, 2Laboratoire de Radiopathologie, SCSR, iRCM, UMR 967, Life Sciences Division, Commissariat à l’Energie Atomique, Fontenay-aux-Roses, France

Patients frequently suffer from cognitive impairments following brain radiotherapy. Ionizing radiations are known to induce various brain alterations and impair neurogenesis. Following whole cerebral irradiation (3X5 Gy), we found significant changes in non-Gaussian water diffusion parameters (ADC0 and kurtosis) and related S-index, a new diffusion biomarker sensitive to changes in tissue microstructure, in the subventricular zone, a site of adult neurogenesis and in the olfactory bulbs. MRS exhibited a longitudinal decrease in taurine specifically in the olfactory bulbs. These results suggest that diffusion MRI and MRS could be used to monitor changes induced by radiation injury.

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