Abstract #4110

Network-wide longitudinal atrophic covariance after ischaemic stroke

Michele Veldsman¹, Amy Brodtmann¹, Graeme Jackson², and Evan Curwood²

¹Stroke Division, The Florey Institute of Neuroscience and Mental Health, Heidelberg, Australia, ²Epilepsy Division, The Florey Institute of Neuroscience and Mental Health, Heidelberg, Australia

Brain atrophy is common after stroke. The extent and pattern of atrophy has not been well investigated and has been limited to localised atrophy and cross-sectional studies, despite network-wide effects of stroke on brain structure and function. We examined correlations in the rate of longitudinal cortical thickness change in stroke patients, compared to healthy age-matched controls. We aimed to investigate whether patterns of neurodegeneration occur in healthy networks as in aging and dementia. We provide evidence of correlations in the rate of cortical atrophy within the DMN suggesting a process of network-based degeneration one year after stroke.

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