Abstract #4120

Noninvasive imaging of oxygen extraction fraction in adults with sickle cell anemia

Lori Jordan¹, Melissa Gindville¹, Allison Scott¹, Meher Juttukonda¹, Megan Strother¹, Adetola Kassim¹, Sheau-Chiann Chen¹, Hanzhang Lu², Sumit Pruthi¹, Yu Shyr¹, and Manus J. Donahue¹

¹Vanderbilt University Medical Center, Nashville, TN, United States, ²Johns Hopkins University, Baltimore, MD, United States

The goal of this work is to apply hemo-metabolic MRI to evaluate relationships between oxygen extraction fraction (OEF), cerebral blood flow (CBF), and clinical impairment in adults with sickle cell anemia (SCA). Healthy (n=11) and sickle cell anemia (n=34) participants received neurological evaluation, head/neck-angiography, structural-MRI, CBF-weighted-MRI, and T2-relaxation-under-spin-tagging (TRUST)-MRI. CBF and OEF were elevated (P<0.05) in SCA relative to control participants; OEF (P<0.0001) but not CBF was increased in SCA participants with higher clinical impairment. Data provide support for TRUST-MRI being able to quickly and noninvasively detect elevated OEF in SCA participants with high levels of clinical impairment.

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