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Abstract #4141

Age-related abnormalities of the corpus callosum in autism spectrum disorder: A diffusion spectrum imaging study using template-based tract-specific analysis

Chien-Hung Lu1, Yu-Jen Chen2, Yu-Chun Lo2, Yu-Chun Hsu2, Susan Shur-Fen Gau3,4, and Wen-Yih Isaac Tseng2,4

1School of Medicine, National Taiwan University, Taipei, Taiwan, 2Institute of Medical Device and Imaging, National Taiwan University, Taipei, Taiwan, 3Department of Psychiatry, National Taiwan University College of Medicine, Taipei, Taiwan, 4Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

The corpus callosum (CC) has been the most investigated white matter tract in autismspectrum disorder (ASD). However, whether the development of the CC is altered in ASD is not clearly identified. In this study, we performed diffusion spectrum imaging using tract specificanalysis to measure the generalized fractional anisotropy of 16 segments of the CC. A GFA–age hyperbolic model was applied to test the age effect. The CC connecting bilateral temporal lobes was signficantly different between ASD and TD. Our results identify the unique time trajectory of the CC in ASD.

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