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Abstract #4178

Association of Apparent Diffusion Coefficient with PFS for recurrent Astrocytoma and Generation of Maps to aid in Defining Tumor Pathology

Evan Neill1, Manisha Dayal1, Joanna Phillips2, Llewellyn Jalbert1, Soonme Cha1, Annette Molinaro2, Susan Chang2, and Sarah Nelson1

1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States

Patients with recurrent low-grade Astrocytomas may experience a large variety of clinical disease courses and outcomes. Diffusion MR imaging and its associations with patient and tumor level characteristics provide an opportunity to use images as maps of tumor aggression and therefore prognosis. This study examines the relationships between the Apparent Diffusion Coefficient (ADC), histology and progress free survival in order to develop a colormap that highlights regions of the tumor with more aggressive characteristics. The colormaps provide an easier way for neuro-oncologists and neurosurgeons to interpret ADC images that can aid them in making decisions about how to manage their patients.

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