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Abstract #4180

ASL, DCE, DSC and IVIM: A 4-way comparison of perfusion imaging in brain tumours

Lawrence Kenning1, Martin D Pickles2, Martin Lowry3, Chris Roland Hill4, Shailendra Achawal4, and Chittoor Rajaraman4

1Centre for MR Investigations, Hull York Medical School, Hull, United Kingdom, 2Centre for MR Investigations, Hull York Medical School at University of Hull, Hull, United Kingdom, 3Hull York Medical School at University of Hull, Hull, United Kingdom, 4Hull and East Yorkshire Hospitals NHS Trust, Hull, United Kingdom

This study aimed to compare Intravoxel Incoherent Motion (IVIM) to more established measures of perfusion; Arterial Spin Labelling (ASL), Dynamic Contrast Enhanced (DCE) and Dynamic Contrast Susceptibility (DSC) imaging, both in tumours and white matter. Mean and 95th percentile values for f, D*, fD*, CBF, Ktrans, ve, vb, rCBV and K2 were calculated. Multiple correlations were observed. Significant correlations of note include CBF vs. fD*, vb vs. rCBV and Ktrans vs. K2. Spatial registration of the 4 different methods yielded acceptable agreement given technical differences.

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