Abstract #4180

ASL, DCE, DSC and IVIM: A 4-way comparison of perfusion imaging in brain tumours

Lawrence Kenning¹, Martin D Pickles², Martin Lowry³, Chris Roland Hill⁴, Shailendra Achawal⁴, and Chittoor Rajaraman⁴

¹Centre for MR Investigations, Hull York Medical School, Hull, United Kingdom, ²Centre for MR Investigations, Hull York Medical School at University of Hull, Hull, United Kingdom, ³Hull York Medical School at University of Hull, Hull, United Kingdom, ⁴Hull and East Yorkshire Hospitals NHS Trust, Hull, United Kingdom

This study aimed to compare Intravoxel Incoherent Motion (IVIM) to more established measures of perfusion; Arterial Spin Labelling (ASL), Dynamic Contrast Enhanced (DCE) and Dynamic Contrast Susceptibility (DSC) imaging, both in tumours and white matter. Mean and 95th percentile values for f, D*, fD*, CBF, K^trans, v_e, v_b, rCBV and K₂ were calculated. Multiple correlations were observed. Significant correlations of note include CBF vs. fD*, v_b vs. rCBV and K^trans vs. K₂. Spatial registration of the 4 different methods yielded acceptable agreement given technical differences.

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