Abstract #4183

Axial diffusivity is more sensitive in detecting white matter injury in adult survivors of childhood brain tumors: a DTI study using tract-based spatial statistics

Silun Wang¹, Jianming Ni², Liya Wang¹, Tricia King³, and Hui Mao¹

¹Department of Radiology and Imaging Sciences, EMORY UNIVERSITY, ATLANTA, GA, United States, ²Medical Imaging Center, The Second Hospital of Wuxi, WuXi, China, People's Republic of, ³Department of Psychology & Neuroscience Institute, Georgia State University, Atlanta, GA, United States

White matter injury is considered as a major contributory factor of treatment-induced neurotoxicity prevalent among childhood cancer survivors. DTI study with TBSS analysis shows significantly lower FA, λ_// and higher λ_⊥ in survivors compared to controls. DTI indices show unmatched white matter regions with significant difference. In comparison of FA, λ_// may be more sensitive to detect white matter injury. Combining analysis of DTI indices provide additional information to explore white matter injury induced by radiotherapy or chemotherapy.

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