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Abstract #4183

Axial diffusivity is more sensitive in detecting white matter injury in adult survivors of childhood brain tumors: a DTI study using tract-based spatial statistics

Silun Wang1, Jianming Ni2, Liya Wang1, Tricia King3, and Hui Mao1

1Department of Radiology and Imaging Sciences, EMORY UNIVERSITY, ATLANTA, GA, United States, 2Medical Imaging Center, The Second Hospital of Wuxi, WuXi, China, People's Republic of, 3Department of Psychology & Neuroscience Institute, Georgia State University, Atlanta, GA, United States

White matter injury is considered as a major contributory factor of treatment-induced neurotoxicity prevalent among childhood cancer survivors. DTI study with TBSS analysis shows significantly lower FA, λ// and higher λ in survivors compared to controls. DTI indices show unmatched white matter regions with significant difference. In comparison of FA, λ// may be more sensitive to detect white matter injury. Combining analysis of DTI indices provide additional information to explore white matter injury induced by radiotherapy or chemotherapy.

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