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Abstract #4185

Correlated MR imaging and ultramicroscopy (MR-UM) is a tool kit to assess the dynamics of glioma angiogenesis

Michael Breckwoldt1, Julia Bode2, Felix Kurz1, Angelika Hoffmann1, Martin Ott2, Katrin Deumelandt2, Gergely Solecki2, Sara Chiblak2, Amir Abdollahi2, Frank Winkler2, Michael Platten2, Sabine Heiland1, Martin Bendszus1, and Björn Tews2

1Neuroradiology, University of Heidelberg, Heidelberg, Germany, 2German Cancer Research Center, Heidelberg, Germany

Gliomas are malignant brain tumors that depend on neoangiogenesis. Novel imaging methods are required to assess vascularization status, treatment effects and disease progression. We developed a combined MR and optical vascularization “tool kit” to study neoangiogenesis in mouse glioma models. We use T2* post contrast imaging (iron oxide nanoparticle or Gd-based) of vascular susceptibility signals and innovative ultramicroscopy (UM) of cleared brains. T2* imaging identifies single arterioles and venules in glioma development. Correlated UM of fluorescently labeled microvessels shows typical features of pathological vessels (increased caliber, density and tortuousness). Thus, MR-UM facilitates the preclinical search for more effective antiangiogenic agents.

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