Abstract #4199

High resolution CBV assessment with PEAK-EPI and PS-SPIRiT-EPI

Rebecca Ramb¹, Anthony G. Christodoulou^2,3, Irina Mader⁴, Maxim Zaitsev¹, Zhi-Pei Liang², and Jürgen Hennig¹

¹University Medical Center Freiburg, Dept. of Radiology - Medical Physics, Freiburg, Germany, ²Beckman Institute, Dept. of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³Heart Institute and Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁴University Medical Center Freiburg, Dept. of Neuroradiology - Freiburg Brain Imaging, Freiburg, Germany

This work is to provide perfusion parameters such as cerebral blood volume at high spatial resolution, for detailed delineation of tumor borders and to guide stereotactic surgery biopsies in locating the most aggressive tumorous tissue. This is achieved with an k-t-undersampled EPI acquisition and PEAK-GRAPPA reconstruction. Additionally, an advanced iterative reconstruction method is developed incorporating partial separability constraint into parallel imaging with SPIRiT kernels (PS-SPIRiT). Two half-dose first-pass perfusion acquisitions in tumor patients allow direct comparison of the standard clinical protocol with the proposed acquisition and reconstruction schemes.

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