Abstract #4209

Optimized image reconstruction for high resolution cerebral blood volume mapping with Ferumoxytol

R. Marc Lebel^1,2,3, Csanad G Varallyay⁴, and Edward A Neuwelt⁴

¹GE Healthcare, Calgary, AB, Canada, ²Radiology, University of Calgary, Calgary, AB, Canada, ³Biomedical Engineering, University of Calgary, Calgary, AB, Canada, ⁴Neurology, Oregon Health and Science University, Portland, OR, United States

Quantitative or semi-quantitative mapping of cerebral blood volume typically involves complex modeling of a dynamic gadolinium-enhanced acquisition. Off-label use of ferumoxytol is being explored as a mechanism for high-resolution quantification of cerebral blood volume. Acquisition involves high-resolution pre- and post-contrast T₂*-weighted scans; quantification is straightforward and does not require fitting. We present a multi-echo acquisition and optimal quantification algorithm for improved detection of ferumoxytol-based blood volume measurements. Our approach provides high dynamic range and minimal noise amplification.

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