Abstract #4213

Accelerating MR measurement of liver steatosis using combined compressed sensing and parallel imaging: quantitative evaluation for clinical trials

Louis W Mann¹, David M Higgins², Carl N Peters¹, Sophie Cassidy¹, Ken K Hodson¹, Anna Coombs¹, Roy Taylor¹, and Kieren Grant Hollingsworth¹

¹Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ²Philips Healthcare, Guildford, United Kingdom

We compared hepatic fat fractions quantified with accelerated magnetic resonance (MR) imaging reconstructed with combined compressed sensing and parallel imaging (CS-PI) with conventional acquisitions. Undersampled data at ratios of 2.6×, 2.9×, 3.8×, and 4.8× were prospectively acquired from eleven subjects with type 2 diabetes and a healthy control. Fat fraction maps were calculated using CS-PI and Bland-Altman analysis. Inter- and intrarater analysis was performed. The fat fractions from the accelerated acquisitions had tight 95% limits of with no bias. The fat fractions were acceptable up to a factor of 3.8×, shortening the breath-hold from 17.7s to 4.7s.

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