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Abstract #4218

Highly accelerated fat-fraction measurements for clinical trials in muscular dystrophy

Thomas Loughran1, David M Higgins2, Anna Coombs1, Michelle McCallum3, Volker Straub3, and Kieren Grant Hollingsworth1

1Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 2Philips Healthcare, Guildford, United Kingdom, 3Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

Fat fraction measurement in muscular dystrophy is important for therapy trials. Accelerated acquisition reconstructed by combined compressed sensing and parallel imaging (CS-PI) can improve patient compliance. Eight patients with Becker muscular dystrophy were recruited and prospectively undersampled data at ratios of 3.65×, 4.94×, and 6.42× were acquired in addition to fully sampled data. The CS-PI reconstructions were of sufficient quality at 3.65× and 4.94× acceleration. Compared to fully sampled data, non-significant bias and 95% limits of agreement of 1.65%, 1.95% and 2.22% were found for the three CS-PI reconstructions, significantly outperforming conventional parallel imaging alone.

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