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Abstract #4223

An Improved Tissue-Fraction MRF (TF-MRF) with Additional Fraction Regularization

Xiaozhi Cao1, Congyu Liao1, Zhixing Wang1, Huihui Ye1, Ying Chen1, Hongjian He1, Song Chen1, Hui Liu2, and Jianhui Zhong1

1Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Zhejiang University, Hangzhou,Zhejiang, China, People's Republic of, 2MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China, People's Republic of

MR fingerprinting has been used for estimating the intra-voxel tissue component fractions by resolving the equation Svoxel=Dw. In this study, potential fractions of interested components are used for building dictionary instead of T1 and T2, changing the solution of Svoxel =Dw into an optimization problem with regularization terms. The results demonstrate that the proposed method could provide more robust quantification of tissue composition and estimation of partial volume effects.

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