Abstract #4228

Highly Accelerated Chemical Exchange Saturation Transfer (CEST) MRI Using Combination of Compressed Sensing and Sensitivity Encoding

Hye-Young Heo^1,2, Yi Zhang¹, Dong-Hoon Lee¹, Shanshan Jiang¹, Xuna Zhao¹, and Jinyuan Zhou^1,2

¹The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Chemical exchange saturation transfer (CEST) imaging is a unique contrast enhancement technique that enables the indirect measurement of endogenous metabolites with water-exchangeable protons. The measurement of a complete Z-spectrum using standard imaging acquisition scheme is time consuming because a large number of the RF saturation frequency offset followed by MR signal readout is inevitable to obtain the full Z-spectrum. In this study, the feasibility of accelerated CEST imaging using combined CS and SENSE technique (CS-SENSE) was demonstrated in healthy volunteers and glioma patients at 3 T.

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