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Abstract #4228

Highly Accelerated Chemical Exchange Saturation Transfer (CEST) MRI Using Combination of Compressed Sensing and Sensitivity Encoding

Hye-Young Heo1,2, Yi Zhang1, Dong-Hoon Lee1, Shanshan Jiang1, Xuna Zhao1, and Jinyuan Zhou1,2

1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Chemical exchange saturation transfer (CEST) imaging is a unique contrast enhancement technique that enables the indirect measurement of endogenous metabolites with water-exchangeable protons. The measurement of a complete Z-spectrum using standard imaging acquisition scheme is time consuming because a large number of the RF saturation frequency offset followed by MR signal readout is inevitable to obtain the full Z-spectrum. In this study, the feasibility of accelerated CEST imaging using combined CS and SENSE technique (CS-SENSE) was demonstrated in healthy volunteers and glioma patients at 3 T.

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