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Abstract #4244

Impact of non-rigid registration and retrospective image correction (RETROICOR) on detecting BOLD fMRI vasomotor response in the breast

Tess E. Wallace1, Andrew J. Patterson2, Roie Manavaki1, Martin J. Graves1, and Fiona J. Gilbert1

1Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 2Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom

Physiological fluctuations and motion artifacts are expected to be dominant sources of noise in BOLD fMRI experiments to assess tumor oxygenation and angiogenesis. This work assesses the impact of a non-rigid registration algorithm and retrospective image correction (RETROICOR) on the detection of activation signals in the breast, both at resting state and in response to a modulated respiratory stimulus paradigm. Our results suggest that correction for motion artifacts is associated with a reduction in false-positive activation effects, which can be further improved by the addition of RETROICOR, confirming the importance of these physiological corrections in functional parameter estimation.

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