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Abstract #4272

Signal-domain optimization metrics for MPRAGE RF pulse design in parallel transmission at 7 Tesla

Vincent Gras1, Alexandre Vignaud1, Franck Mauconduit2, Michel Luong3, Alexis Amadon1, Denis Le Bihan1, and Nicolas Boulant1

1Neurospin, CEA/DSV/I2BM, Gif-sur-Yvette, France, 2Siemens Healthcare, Saint-Denis, France, 3IRFU, CEA/DSM, Gif-sur-Yvette, France

The standard approach to design radiofrequency pulses in MRI is to minimize the deviation of the flip angle from a target value. An alternative approach is proposed here for the MPRAGE sequence which uses the signal as a surrogate of the flip angle in the optimization of the excitation and inversion pulses. The results obtained in simulation and in the brain in vivo on a parallel transmission enabled 7T scanner show two possible applications of the method: an improvement in image quality or a significant reduction of the SAR at equivalent image quality.

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