Abstract #4272

Signal-domain optimization metrics for MPRAGE RF pulse design in parallel transmission at 7 Tesla

Vincent Gras¹, Alexandre Vignaud¹, Franck Mauconduit², Michel Luong³, Alexis Amadon¹, Denis Le Bihan¹, and Nicolas Boulant¹

¹Neurospin, CEA/DSV/I2BM, Gif-sur-Yvette, France, ²Siemens Healthcare, Saint-Denis, France, ³IRFU, CEA/DSM, Gif-sur-Yvette, France

The standard approach to design radiofrequency pulses in MRI is to minimize the deviation of the flip angle from a target value. An alternative approach is proposed here for the MPRAGE sequence which uses the signal as a surrogate of the flip angle in the optimization of the excitation and inversion pulses. The results obtained in simulation and in the brain in vivo on a parallel transmission enabled 7T scanner show two possible applications of the method: an improvement in image quality or a significant reduction of the SAR at equivalent image quality.

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