Abstract #4291

Characterising and Modelling Susceptibility Artifacts in the Mouse Brain at 9.4 T

Rosie Goodburn¹, Nicholas Powell^2,3, James O’Callaghan², Simon Walker-Samuel², and Karin Shmueli¹

¹Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ²UCL Centre for Advanced Biomedical Imaging, Division of Medicine, London, United Kingdom, ³UCL Centre for Medical Imaging Computing, London, United Kingdom

Susceptibility artifacts hamper gradient-echo MRI of the mouse brain at 9.4 Tesla. Here, we characterised and modelled magnetic field maps aiming to improve preclinical mouse MRI. To characterise field perturbations, we measured and coregistered field maps in 7 mice to create a group-average field map. Next, a Fourier forward model was used to simulate a field map based on a susceptibility distribution constructed from the group-average magnitude image. The measured and modelled field maps showed similar qualitative field patterns, especially around the aural air cavities, but had quantitative differences. Work is ongoing to improve the accuracy of the model.

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