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Abstract #4322

Partial volume correction of quantitative susceptibility maps for oxygen extraction fraction measurements.

Phillip G. D. Ward1,2, Audrey P. Fan3, Parnesh Raniga1, David G. Barnes2,4, David L. Dowe2, and Gary F. Egan1,5

1Monash Biomedical Imaging, Monash University, Clayton, Australia, 2Faculty of Information Technology, Monash University, Clayton, Australia, 3Lucas Center for Imaging, Department of Radiology, Stanford University, Stanford, CA, United States, 4Monash eResearch Centre, Monash University, Clayton, Australia, 5ARC Centre of Excellence for Integrative Brain Function, Melbourne, Australia

Partial volume effects impede the use of quantitative susceptibility maps for assessing small veins. Oxygen extraction fraction measures are particularly sensitive to these effects. We propose a geometric technique for calculating partial volume from binary venograms. The technique is able to calculate accurate partial volume maps, and vessel geometry, on simulated veins of sub-voxel radius. These partial volume maps are used to adjust for partial volume effects in estimating venous magnetic susceptibility.

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