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Abstract #4337

Comparing MRI texture heterogeneity with MTR and myelin water fraction as measures of myelin integrity

Tim Luo1, Shrushrita Sharma2, Mark Polivchuk3, Peng Zhai4, and Yunyan Zhang4

1Bachelor of Health Sciences, University of Calgary, Calgary, AB, Canada, 2Biomedical Engineering Program, University of Calgary, Calgary, AB, Canada, 3Computer Science, University of Calgary, Calgary, AB, Canada, 4Radiology and Clinical Neurosciences, University of Calgary, Calgary, AB, Canada

Changes in myelin integrity are associated with many neurological diseases. We acquired 9.4T MRI from healthy mouse brain to evaluate the utility of texture heterogeneity in T2-weighted MRI for assessing myelin integrity, in comparing with proposed measures including magnetic transfer ratio and myelin water fraction. Measurements were focused on the corpus callosum, with both anatomical (genu, body, splenium) and hemispheric (left, center, right) locations evaluated. All 3 methods showed the uniformity of myelin in corpus callosum between hemispheres, and no significant differences between anatomical locations were detected. Texture heterogeneity showed the best consistency between animals and deserves further verification.

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