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Abstract #4344

Adiabatic T2-Prepared 3D Fast Gradient Echo Imaging for Brain Tumor Studies at 7T

Peng Cao1, Angela Jakary1, Yan Li1, Sarah J. Nelson1, Doug Kelley2, and Peder E. Z. Larson1

1Department of Radiology, University of California at San Francisco, San Francisco, CA, United States, 2GE Healthcare, Waukesha, WI, United States

Mechanisms to create a homogenous T2 contrast at 7T should be robust to both B0 and B1 inhomogeneities. This issue was addressed by applying a zero-degree BIR-4 adiabatic pulse for T2 preparation. Simulation and in vivo experiments in mouse brain verified the robustness and contrast of the preparation scheme at 7T. Application of this method was further demonstrated in a study of a patient with a brain tumor. The adiabatic T2 weighting showed high intensity in the region of the tumor, suggesting that the proposed method is likely to be useful in screening and characterizing tumors.

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