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Abstract #4372

Assessment of cortical cerebrovascular permeability using 3-dimension pseudo-continuous arterial spin labeling and T1 dynamic contrast enhancement magnetic resonance imaging in moyamoya disease

Yan Ren1, Qian Zhou1, Haopeng Pang1, Yong Zhang2, Zihua Su3, and Zhenwei Yao1

1Huashan Hospital, Fudan University, Shanghai, China, People's Republic of, 2MR Research, GE Healthcare, Shanghai, China, People's Republic of, 3Advanced application, GE Healthcare, Beijing, China, People's Republic of

In moyamoya disease (MMD), the compensatory collateralization from external cerebral artery or bypass artery is essential to evaluate the severity of disease and perfusion efficacy of surgical revascularization. And the leptomeningeal anastomoses were regarded as significant contributors to the collateral blood supply. However, the characteristic of the compensatory collateralization has not been clarified up to now, such as the permeability of vessels, which could be the reason of rehemarrhage and other complications after the surgical revascularization for MMD. We hypothesize the high permeability of collateralization leads to rehemarrhage in MMD. In this work, quantitative assessment of 3D-pCASL and DCE-MRI suggests no significant increased permeability in the cortical areas with collateral neovascularization in MMD.

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