Abstract #4374

Intracranial vessel wall and cerebrovascular reactivity imaging provides evidence for mechanistic differences in atherosclerotic and non-atherosclerotic stenotic disease

Petrice M Cogswell¹, L Taylor Davis¹, Megan K Strother², Carlos C Faraco¹, Lori C Jordan³, Blaise deB Frederick⁴, Jeroen Hendrikse⁵, and Manus J Donahue¹

¹Radiology, Vanderbilt University, Nashville, TN, United States, ²DXP Imaging, Louisville, KY, United States, ³Neurology, Vanderbilt University, Nashville, TN, United States, ⁴McLean Hospital, Boston, MA, United States, ⁵University Medical Center Utrecht, Utrecht, Netherlands

No study to date has assessed the relationship between intracranial vessel plaque and wall thickening and its impact on tissue-level function. A novel intracranial vessel wall imaging protocol and BOLD imaging were applied in patients with intracranial stenosis secondary to atherosclerosis and moyamoya disease (non-atherosclerotic stenosis). The time of maximum correlation of BOLD data with the applied stimulus, the CVR time, calculated using a novel time regression technique, is prolonged in vascular territories with a proximal vessel wall lesion for both atherosclerosis and moyamoya patients. The maximum z-statistic, a qualitative metric of CVR, is decreased in vascular territories with a proximal vessel wall lesion in moyamoya patients only.

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