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Abstract #4379

Iterative algorithm for the temporal decomposition of the cerebrovascular reactivity dynamic response in neurovascular patients.

Marco Piccirelli1, Christiaan Hendrik Bas van Niftrik2, Oliver Bozinov2, Athina Pangalu1, Antonio Valavanis1, Luca Regli2, and Jorn Fierstra2

1Department of Neuroradiology, University Hospital Zurich, Zurich, Switzerland, 2Department of Neurosurgery, University Hospital Zurich, Zurich, Switzerland

Our iterative algorithm evaluates transient phases of BOLD fMRI signal dynamics during a CO2 pseudo-square wave challenge and optimizes CO2 arrival time determination to increase sensitivity and reliability of cerebrovascular reactivity analysis. On 25 healthy controls and unilateral internal carotid occlusion patients, all BOLD-derived parameters maps are normalized in MNI space and combined for reference atlases and assess alterations within single patient. The transient phase durations, temporal delay maps and dynamic and static CVR maps were calculated. We determined the optimal CO2 arrival time and found that excluding the transient phases resulted in the best fit to the physiological data.

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