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Abstract #4395

Magnetisation Transfer Ratio (MTR) Measurements in the Lumbar cord: A Pilot Study using ZOOM-EPI at 3T

Rebecca Sara Samson1, Marco Battiston1, Claudia Angela Michela Gandini Wheeler-Kingshott1,2, and Marios C Yiannakas1

1NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, University College London, London, United Kingdom, 2Brain Connectivity Center, C. Mondino National Neurological Institute, Pavia, Italy

The Magnetisation Transfer Ratio (MTR), and quantitative Magnetisation Transfer (MT) parameters have proven to be sensitive to the diseased spinal cord (SC), however in vivo quantitative imaging of the cord is challenging. Rapid acquisition sequences such as Echo Planar Imaging (EPI) are desirable but may suffer from artefacts and image distortions. Here we present results from the use of single-shot ZOOM-EPI to reduce acquisition time and distortions in SC MTR mapping. The mean SC MTR value for 9 subjects was 38.8 (±4.05). The mean scan-rescan coefficient of variation for measuring SC MTR (from 5 subjects) was 4.39%.

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