Abstract #4400

fMRI of lumbar spinal cord during electrical stimulation in diabetic patients

Zhiwei Shen¹, Yanlong Jia¹, Tingting Nie¹, Tao Zhang¹, Gen Yan¹, and Renhua Wu¹

¹The 2nd Affilited Hosptial of Shantou Universtiy Medical College, Shantou, China, People's Republic of

Diabetic peripheral neuropathy (DPN) is one of the main complications of long-term diabetes and the incidence is 60% to 90%. However, there is no objective noninvasive method to detect the degree of damage of DPN and its pathogenesis remains unknown. Functional magnetic resonance imaging (fMRI) has the advantages of high spatial and temporal resolution, which had been used to detect neuron activity. In this study, the activation in the lumbar spinal cord of by electric stimulation were detected. Elevated activation percentage changes of DPN were found and the activation changes have the correlated relatioship with blood biochemical indexes such as glucose, the total cholesterol and haemoglobin A1c.

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