Abstract #4404

Ultra-high-resolution postmortem imaging of marmoset EAE spinal cords

Jennifer Lefeuvre^1,2, Joseph R Guy¹, Nick Luciano¹, Emily Leibovitch¹, Mathieu D Santin², Afonso C Silva¹, Steve Jacobson¹, Stéphane Lehericy², Daniel S Reich¹, and Pascal Sati¹

¹NINDS, NIH, Bethesda, MD, United States, ²INSERM U1127/CNRS UMR7225, CENIR, Brain and Spine Institute, Paris, France

Multiple sclerosis (MS) is a demyelinating disease that affects the entire central nervous system, with more than 90% of patients showing focal or diffuse abnormalities in the spinal cord (SC). Experimental autoimmune encephalomyelitis (EAE) in marmosets is an attractive animal model of MS due to its radiological presentation with brain lesions that mimic MS¹. However, spinal cord lesions in marmoset EAE have not yet been well characterized. The proposed methodology allows high-quality, high-resolution imaging of SC lesions in autopsied marmosets with EAE. The artifact-free images allowed accurate detection of focal and confluent rim lesions along the edges of the SC.

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