Abstract #4430

Microstructural organization of the language connectome in typically developing left-handed children: a DTI tractography study

Marjolein Verly¹, Robin Gerrits¹, Lieven Lagae², Inge Zink¹, Stefan Sunaert³, and Nathalie Rommel¹

¹Dept. Neurosciences, KU Leuven, Leuven, Belgium, ²Dept. Pediatrics, UZ Leuven, Leuven, Belgium, ³Dept. Translational MRI, KU Leuven, Leuven, Belgium

The main objective of this study was to investigate the relationship between the microstructural properties of language-related white matter (WM) tracts and hand preference in typically developing school-aged children. Our DTI tractography results provide evidence for a different structural connectivity pattern of the language connectome in left-handed children. Whereas right-handed children show a clear left-lateralized structural language network, our group of left-handed children seems to have a more bilateral organized language system. Those observed differences in WM microstructure and lateralization might reflect an interaction between handedness and the neural processing of language in children.

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