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Abstract #4430

Microstructural organization of the language connectome in typically developing left-handed children: a DTI tractography study

Marjolein Verly1, Robin Gerrits1, Lieven Lagae2, Inge Zink1, Stefan Sunaert3, and Nathalie Rommel1

1Dept. Neurosciences, KU Leuven, Leuven, Belgium, 2Dept. Pediatrics, UZ Leuven, Leuven, Belgium, 3Dept. Translational MRI, KU Leuven, Leuven, Belgium

The main objective of this study was to investigate the relationship between the microstructural properties of language-related white matter (WM) tracts and hand preference in typically developing school-aged children. Our DTI tractography results provide evidence for a different structural connectivity pattern of the language connectome in left-handed children. Whereas right-handed children show a clear left-lateralized structural language network, our group of left-handed children seems to have a more bilateral organized language system. Those observed differences in WM microstructure and lateralization might reflect an interaction between handedness and the neural processing of language in children.

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