MR spectroscopy predicts injury in a variable rat model of epilepsy
Yijen Wu1, Patrice S Pearce2, Amedeo Rapuano3, Kevin Kelly2, Nihal de Lanerolle3, and Jullie W Pan4
1Developmental Biology, University of Pittsburgh, Pittsburgh, PA, United States, 2Pittsburgh, PA, United States, 3New Haven, CT, United States, 4University of Pittsburgh, Pittsburgh, PA, United States
MR spectroscopy in a variable rat status epilepticus (kainate induced) model of epilepsy is shown to segregate between mildly and severely injured animals. As measured 3days after status epilepticus, animals with NAA/tCr values of less than 1.0 (kainate more injured, KMI) segregated with greater increases in Inositol/tCr, Glutamine/tCr and Lac/tCr, with these changes predicting the metabolic measured 3weeks after status. Although Inositol/tCr was elevated in the kainate less injured KLI group, the KLI group showed milder changes at 3days and at 3weeks. This metabolic classification was also sustained into histologic studies.
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