Abstract #4450

MR spectroscopy predicts injury in a variable rat model of epilepsy

Yijen Wu¹, Patrice S Pearce², Amedeo Rapuano³, Kevin Kelly², Nihal de Lanerolle³, and Jullie W Pan⁴

¹Developmental Biology, University of Pittsburgh, Pittsburgh, PA, United States, ²Pittsburgh, PA, United States, ³New Haven, CT, United States, ⁴University of Pittsburgh, Pittsburgh, PA, United States

MR spectroscopy in a variable rat status epilepticus (kainate induced) model of epilepsy is shown to segregate between mildly and severely injured animals. As measured 3days after status epilepticus, animals with NAA/tCr values of less than 1.0 (kainate more injured, KMI) segregated with greater increases in Inositol/tCr, Glutamine/tCr and Lac/tCr, with these changes predicting the metabolic measured 3weeks after status. Although Inositol/tCr was elevated in the kainate less injured KLI group, the KLI group showed milder changes at 3days and at 3weeks. This metabolic classification was also sustained into histologic studies.

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