Abstract #4452

Probiotics as possible treatment in Chronic Liver Disease-induced Hepatic Encephalopathy, an in vivo longitudinal 1H MRS study in a rat model

Veronika Rackayova¹, Olivier Braissant², Corina Berset³, Jocelyn Grosse⁴, Daniela Capobianco⁵, Paola Mastromarino⁵, Valérie A. McLin⁶, and Cristina Cudalbu³

¹Laboratory of Functional and Metabolic Imaging, Center for Biomedical Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Vaud, Switzerland, Lausanne, Switzerland, ²Service of Biomedicine, University Hospital of Lausanne, Lausanne, Vaud, Switzerland, Lausanne, Switzerland, ³Center for Biomedical Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Vaud, Switzerland, Lausanne, Switzerland, ⁴Laboratory of behavioral genetics, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Vaud, Switzerland, Lausanne, Switzerland, ⁵Sapienza University of Rome, Department of Public Health and Infectious diseases, Section of Microbiology, Rome, Italy, Rome, Italy, ⁶Swiss Center for Liver Disease in Children, Department of Pediatrics, University Hospitals Geneva, Geneva, Switzerland, Geneva, Switzerland

We investigated potential therapeutic effect of probiotic treatment with anti-inflammatory proprieties (VSL#3) in a rat model of Chronic Liver Disease induced Hepatic Encephalopathy (HE). ¹H MRS at 9.4T revealed significantly lower increase of glutamine (typical sign of HE) and better osmoregulation in the hippocampus together with overall better performance in behavioural tests in treated animals. These results are very promising.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.