Abstract #4452

Probiotics as possible treatment in Chronic Liver Disease-induced Hepatic Encephalopathy, an in vivo longitudinal 1H MRS study in a rat model

Veronika Rackayova¹, Olivier Braissant², Corina Berset³, Jocelyn Grosse⁴, Daniela Capobianco⁵, Paola Mastromarino⁵, Valérie A. McLin⁶, and Cristina Cudalbu³

¹Laboratory of Functional and Metabolic Imaging, Center for Biomedical Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Vaud, Switzerland, Lausanne, Switzerland, ²Service of Biomedicine, University Hospital of Lausanne, Lausanne, Vaud, Switzerland, Lausanne, Switzerland, ³Center for Biomedical Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Vaud, Switzerland, Lausanne, Switzerland, ⁴Laboratory of behavioral genetics, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Vaud, Switzerland, Lausanne, Switzerland, ⁵Sapienza University of Rome, Department of Public Health and Infectious diseases, Section of Microbiology, Rome, Italy, Rome, Italy, ⁶Swiss Center for Liver Disease in Children, Department of Pediatrics, University Hospitals Geneva, Geneva, Switzerland, Geneva, Switzerland

We investigated potential therapeutic effect of probiotic treatment with anti-inflammatory proprieties (VSL#3) in a rat model of Chronic Liver Disease induced Hepatic Encephalopathy (HE). ¹H MRS at 9.4T revealed significantly lower increase of glutamine (typical sign of HE) and better osmoregulation in the hippocampus together with overall better performance in behavioural tests in treated animals. These results are very promising.

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