Abstract #4454

Prenatal exposure to common insecticide Malathion selectively alters micro-structural architecture in male guinea pigs

Su Xu^1,2, Shiyu Tang^1,2, Roger J Mullins^1,2, Edna FR Pereira³, Edson X Albuquerque³, and Rao P Gullapalli^1,2

¹Radiology, University of Maryland School of Medicine, Baltimore, MD, United States, ²Core for Translational Research in Imaging @ Maryland, Baltimore, MD, United States, ³Department of Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, United States

To test the hypothesis that prenatal exposure of guinea pigs to malathion, one of the few organophosphate insecticides that is still in residential use in the USA, disrupts axonal integrity. After the sub-acute maternal exposure to malathion, male offspring of exposed mothers had significantly decreased diffusion metrics and anisotropy in the corpus callosum. The findings reveal the lasting effect of prenatal exposure to malathion and the danger of mother to child transmission of malathion in the environment.

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