Follow-up analyses on the effects of long-term use of high fat diet on hippocampal volumes and hippocampal metabolite concentrations in Wistar rats: a voxel based morphology and 1H MRS approach
Piotr Majka1, Bartosz Kossowski2, Jarosław Orzeł2, Piotr Bogorodzki2, Zuzanna Setkowicz3, and Stefan P. Gazdzinski4
1Nencki Institute for Experimenal Biology, Warsaw, Poland, 2Warsaw University of Technology, Warsaw, Poland, 3Neuroanatomy, Jagiellonian University, Krakow, Poland, 4CNS Lab, Military Institute for Aviation Medicine, Warsaw, Poland
Our study
of long-term use of high fat diet inducing mild ketonemia in Wistar rats showed
improvements in learning and memory, as well as larger hippocampi and higher
concentrations of tNAA (marker of neuronal viability), tCho (involved in
metabolite turnover), and tCr (involved in cell energetics). Here, we applied
voxel based morphometry (VBM) for structural images and used TARQUIN for 1H MRS
data obtained at 7T. Results of VBM and TARQUIN provided results consistent
with previous analyses. However, the use of a literature-based template lead to
tissue contractions not detectable with study specific template.
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