Abstract #4457

Follow-up analyses on the effects of long-term use of high fat diet on hippocampal volumes and hippocampal metabolite concentrations in Wistar rats: a voxel based morphology and 1H MRS approach

Piotr Majka¹, Bartosz Kossowski², Jarosław Orzeł², Piotr Bogorodzki², Zuzanna Setkowicz³, and Stefan P. Gazdzinski⁴

¹Nencki Institute for Experimenal Biology, Warsaw, Poland, ²Warsaw University of Technology, Warsaw, Poland, ³Neuroanatomy, Jagiellonian University, Krakow, Poland, ⁴CNS Lab, Military Institute for Aviation Medicine, Warsaw, Poland

Our study of long-term use of high fat diet inducing mild ketonemia in Wistar rats showed improvements in learning and memory, as well as larger hippocampi and higher concentrations of tNAA (marker of neuronal viability), tCho (involved in metabolite turnover), and tCr (involved in cell energetics). Here, we applied voxel based morphometry (VBM) for structural images and used TARQUIN for ¹H MRS data obtained at 7T. Results of VBM and TARQUIN provided results consistent with previous analyses. However, the use of a literature-based template lead to tissue contractions not detectable with study specific template.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.