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Abstract #4457

Follow-up analyses on the effects of long-term use of high fat diet on hippocampal volumes and hippocampal metabolite concentrations in Wistar rats: a voxel based morphology and 1H MRS approach

Piotr Majka1, Bartosz Kossowski2, Jarosław Orzeł2, Piotr Bogorodzki2, Zuzanna Setkowicz3, and Stefan P. Gazdzinski4

1Nencki Institute for Experimenal Biology, Warsaw, Poland, 2Warsaw University of Technology, Warsaw, Poland, 3Neuroanatomy, Jagiellonian University, Krakow, Poland, 4CNS Lab, Military Institute for Aviation Medicine, Warsaw, Poland

Our study of long-term use of high fat diet inducing mild ketonemia in Wistar rats showed improvements in learning and memory, as well as larger hippocampi and higher concentrations of tNAA (marker of neuronal viability), tCho (involved in metabolite turnover), and tCr (involved in cell energetics). Here, we applied voxel based morphometry (VBM) for structural images and used TARQUIN for 1H MRS data obtained at 7T. Results of VBM and TARQUIN provided results consistent with previous analyses. However, the use of a literature-based template lead to tissue contractions not detectable with study specific template.

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