Abstract #4465

Radiation-induced Early Temporal Changes of IVIM-based Diffusion and Perfusion Patterns of Bone Marrow Predict the Likelihood of Hematological Toxicity

Elaine Yuen Phin Lee¹, Jian He², Jose Angelo Udal Perucho¹, and Queenie Chan³

¹The Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong, ²Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China, People's Republic of, ³Philips Healthcare, Hong Kong, Hong Kong

Intravoxel incoherent motion (IVIM) diffusion-weighted MRI offers the unique opportunity to simultaneously study the diffusion and perfusion changes in the bone marrow following whole-pelvis radiotherapy. We prospectively studied twenty-eight patients with cervical cancer who had paired IVIM MRI examinations before and at week-4 of treatment. We observed a distinctive positive trend of D (true diffusion coefficient) in patients who suffered hematological toxicity (HT), whilst D remained relatively stable in patients who did not suffer HT. In addition, f (perfusion fraction) increased following treatment, but this pattern was not unique to patients who suffered HT.

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