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Abstract #4465

Radiation-induced Early Temporal Changes of IVIM-based Diffusion and Perfusion Patterns of Bone Marrow Predict the Likelihood of Hematological Toxicity

Elaine Yuen Phin Lee1, Jian He2, Jose Angelo Udal Perucho1, and Queenie Chan3

1The Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong, 2Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China, People's Republic of, 3Philips Healthcare, Hong Kong, Hong Kong

Intravoxel incoherent motion (IVIM) diffusion-weighted MRI offers the unique opportunity to simultaneously study the diffusion and perfusion changes in the bone marrow following whole-pelvis radiotherapy. We prospectively studied twenty-eight patients with cervical cancer who had paired IVIM MRI examinations before and at week-4 of treatment. We observed a distinctive positive trend of D (true diffusion coefficient) in patients who suffered hematological toxicity (HT), whilst D remained relatively stable in patients who did not suffer HT. In addition, f (perfusion fraction) increased following treatment, but this pattern was not unique to patients who suffered HT.

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