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Abstract #4472

Differentiation of spinal lesions using monoexponential, biexponential, and gamma distribution diffusion-weighted MR Imaging: Initial clinical results

Miyuki Takasu1, Yuji Akiyama1, Chihiro Tani1, Yoko Kaichi1, Takayuki Tamura1, Koichi Oshio2, and Kazuo Awai1

1Diagnostic Radiology, Hiroshima University Hospital, Hiroshima-shi, Japan, 2Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo, Japan

The purpose of this study was to quantitatively compare various diffusion parameters obtained from monoexponential, biexponential, and gamma distribution models in differentiating vertebral lesions in human subjects. All MR parameters, except for ADCfast and frac > 3, were significantly different between normal bone marrow and lesions. Water molecular diffusion parameters may provide additional information and improve the differentiation of spinal lesions compared with conventional diffusion parameters. This also refers to differentiation of malignant lesions from acute spinal fracture, in which both PG (D) calculated from gamma distribution model and perfusion fraction f of the biexponential model proved to be useful.

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