Abstract #4472

Differentiation of spinal lesions using monoexponential, biexponential, and gamma distribution diffusion-weighted MR Imaging: Initial clinical results

Miyuki Takasu¹, Yuji Akiyama¹, Chihiro Tani¹, Yoko Kaichi¹, Takayuki Tamura¹, Koichi Oshio², and Kazuo Awai¹

¹Diagnostic Radiology, Hiroshima University Hospital, Hiroshima-shi, Japan, ²Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo, Japan

The purpose of this study was to quantitatively compare various diffusion parameters obtained from monoexponential, biexponential, and gamma distribution models in differentiating vertebral lesions in human subjects. All MR parameters, except for ADCfast and frac > 3, were significantly different between normal bone marrow and lesions. Water molecular diffusion parameters may provide additional information and improve the differentiation of spinal lesions compared with conventional diffusion parameters. This also refers to differentiation of malignant lesions from acute spinal fracture, in which both PG (D) calculated from gamma distribution model and perfusion fraction f of the biexponential model proved to be useful.

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