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Abstract #4493

Repeatability of R1ρ, R2, and R2* in Knee Cartilage

Joshua Kaggie1, Scott Reid2, Gavin Houston2, Kevin F King3, Ferdia Gallagher1, and Martin Graves1

1Radiology, University of Cambridge, Cambridge, United Kingdom, 2GE Healthcare, Amersham, United Kingdom, 3GE Healthcare, Milwaukee, WI, United States

R1ρ, R2, and R2* imaging have been considered as biomarkers of degenerative cartilage diseases. In order to ensure the reliability of these measurements, we acquired data in eight subjects twice and compared measurements of variability. R1ρ-measurements had lower variability (CVRMS=21%) and a higher correlation to age (r2-value=0.566) when compared to R2 (r2-value=0.183; CVRMS=25%) and R2* (r2-value=0.092; CVRMS=38%). These measurements suggest that R1ρ is a more sensitive biomarker than R2 or R2*.

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