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Abstract #4495

Spotlight on gagCEST imaging in human menisci with MR-microimaging on ultra-high field 7T - a pilot study

Benedikt Hager1,2,3, Sonja Walzer3, Matthew DiFranco4, Vladimir Juras1,5, Vladimir Mlynarik1,2, Markus Schreiner3, Martin Zalaudek1, Stefan Domayer3, Esau Poblador Rodriguez1, Andreas Berg4, Reinhard Windhager3, and Siegfried Trattnig1,2

1High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 3Department of Orthopaedic Surgery, Medical University of Vienna, Vienna, Austria, 4Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, 5Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia

The purpose of this study was to examine whether gagCEST imaging reflects the histopathological changes concerning glycosaminoglycan in human meniscus in vitro. All MRI acquisitions were performed on 7T MRI with a microimaging system. Histological staining using safranin-O was performed for correlation to imaging findings. Qualitatively, the gagCEST map and the corresponding safranin-O image show the same relative regional intensity of glycosaminoglycans. In sum, gagCEST imaging in a 7T microimaging system allows a very detailed look into the glycosaminoglycan distribution in the human meniscus.

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